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Acetamidine HCl

Acetamidine hydrochloride

CAS: 124-42-5

Molecular Formula: C2H7ClN2

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Acetamidine HCl - Names and Identifiers

Name Acetamidine hydrochloride
Synonyms Acetamidine
Acetamidine HCl
(1E)-ethanimidamide
ACETAMIDINIUM CHLORIDE
acetamidinium chloride
ACEDIAMINE HYDROCHLORIDE
ACECAMIDINE HYDROCHLORIDE
Acetamidine hydrochloride
Ethylamidinehydrochloride
Ethaneamidinehydrochloride
Acetalmidine hydrochioride
Ethanimidamide hydrochloride
ethanimidamide,monohydrochloride
CAS 124-42-5
EINECS 204-700-9
InChI InChI=1/C2H6N2/c1-2(3)4/h1H3,(H3,3,4)
InChIKey WCQOBLXWLRDEQA-UHFFFAOYSA-N

Acetamidine HCl - Physico-chemical Properties

Molecular FormulaC2H7ClN2
Molar Mass94.54
Density1.0596 (rough estimate)
Melting Point165-170°C(lit.)
Boling Point129.78°C (rough estimate)
Water Solubility1 g/mL
Vapor Presure176mmHg at 25°C
AppearanceWhite crystal
ColorWhite to cream
Merck14,44
BRN3591762
pKapK1: 1.60(+1) (25°C)
Storage ConditionInert atmosphere,Room Temperature
SensitiveHygroscopic
Refractive Index1.5500 (estimate)
MDLMFCD00013016
Physical and Chemical PropertiesCharacter: White long prism-like crystal, easy to deliquescence, with abnormal odor.
soluble in water, insoluble in acetone and ether.
UseAn important intermediate for the synthesis of vitamin B1, the basic raw materials for organic synthesis

Acetamidine HCl - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk CodesR36/37/38 - Irritating to eyes, respiratory system and skin.
R36/38 - Irritating to eyes and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39 - Wear suitable gloves and eye/face protection
WGK Germany3
FLUKA BRAND F CODES3
TSCAYes
HS Code29252000

Acetamidine HCl - Upstream Downstream Industry

Raw MaterialsMethyl alcohol
Methyl alcohol
Chlorosulfonic acid
Chlorosulfonic acid
Ammonia
Acetonitrile
Acetonitrile
Phosphoric acid
Phosphoric acid

Acetamidine HCl - Nature

Open Data Verified Data

White long prism-like crystals, easy to deliquescence, there are odor. Soluble in water, in acetone, ether insoluble.

Last Update：2024-01-02 23:10:35

Acetamidine HCl - Preparation Method

Open Data Verified Data

with acetonitrile, hydrochloric acid and methanol as raw materials, by addition, ammoniation and. First, 45% hydrogen chloride methanol solution was prepared in the turbulent ball column, and then put into the reaction tank. After stirring and cooling, acetonitrile was added at 8~11 ℃, and at 15~20 ℃, the mixture was incubated for 6 hours to obtain ether. Then add ammonia methanol solution, after stirring, the reaction, the pH value is always maintained in the range of 7~8, after cooling, by centrifugal separation, filtering out ammonium chloride, the filtrate was concentrated and centrifuged to obtain a finished product.

Last Update：2022-01-01 10:37:31

Acetamidine HCl - Introduction

Solubility in water: 1G/ML, soluble in alcohol, insoluble in acetone and ether. When added to the lye, it will free precipitate acetamidine, which is strongly alkaline, and it will be decomposed into ammonia and acetic acid by micro heating.
Last Update：2022-10-16 17:12:56

Acetamidine HCl - Use

Open Data Verified Data

used as a pharmaceutical intermediate to produce vitamin B1.

Last Update：2022-01-01 10:37:30

Acetamidine HCl - Safety

Open Data Verified Data

This product is packed with polyethylene film bag, each 25kg.

Last Update：2022-01-01 10:37:31

Acetamidine HCl - Reference Information

EPA chemical information Information provided by: ofmpub.epa.gov (external link)
introduction acetamidine hydrochloride is needle-like or prismatic crystal obtained from ethanol with a melting point of 177~178 ℃. Soluble in water and ethanol, insoluble in acetone, ether and benzene. When its salt meets alkali, it produces acetamidine (acetamidine reacts alkaline), and its aqueous solution can be decomposed into ammonia and acetic acid when heated, and should be stored in a cold place.
use acetamidine hydrochloride is the main raw material for the production of vitamin B1 and an important monomer in organic synthesis.
It is an important intermediate for the synthesis of vitamin B1, and it is also used as a raw material for organic synthesis
Acetamidine hydrochloride is an intermediate of the organophosphorus rodenticide and brominated rodentiophos. It is also an intermediate of vitamin B1 in medicine.
Mainly used as an intermediate raw material for vitamin B1, and can also be used as a basic raw material for organic synthesis.
An important intermediate for the synthesis of vitamin B1, the basic raw material for organic synthesis
Acetamidine hydrochloride is a pharmaceutical intermediate used to produce vitamin B1. It is an intermediate of rodenticide
used for the production of pharmaceutical vitamin B1, used as a basic raw material for the synthesis of imidazole, pyrimidine, and triazine antibiotics, and also used for the synthesis of vitamin B1
Production method The preparation method is obtained by addition and ammoniation of acetonitrile, hydrochloric acid and methanol. The methanol is circulated in the turbulent ball tower, and dry hydrogen chloride is introduced under cooling to make a 45% hydrogen chloride methanol solution. Then put into the reaction tank, stir and cool to 5~10 ℃, add acetonitrile dropwise, and keep the temperature at 15~20 ℃ for 6 h to obtain iminomethyl ether hydrochloride. Put it into the pre-prepared 13% ammonia methanol solution, ammonolysis at 0~40 ℃, keep pH = 7~8, stir for 2~3 hours, cool to below 30 ℃, centrifuge to filter out ammonium chloride. The filtrate recovers methanol and cools and filters to obtain the finished product.
It is obtained by addition and ammoniation of acetonitrile, hydrochloric acid and methanol. The methanol is circulated in the turbulent ball tower at a pressure of less than 26.6kPa, and dry hydrogen chloride is introduced under cooling to prepare a hydrogen chloride methanol solution with a concentration of 45%. Then put it into a reaction tank, stir and cool to 10-5 ℃, add acetonitrile dropwise, and keep the temperature at 15-20 ℃ for 6 hours to obtain iminyl methyl ether hydrochloride. Put it into the pre-prepared 13% ammonia methanol solution, ammonolysis at 0-40 ℃, keep the pH value of 7-8, stir for 2-3h, cool to below 30 ℃, centrifugally separate and filter out ammonium chloride. The filtrate recovers methanol and cools and filters to obtain the finished product. Weight feed ratio: acetonitrile: hydrogen chloride methanol solution (45%): ammonia: methanol = 1:3:1.05:4.3. Yield 82%-85%.
Last Update：2024-04-09 02:00:06
Acetamidine HCl
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CAS: 124-42-5
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Hangzhou Verychem Science And Technology Co.Ltd
Product Name: Acetamidine hydrochloride Request for quotation
CAS: 124-42-5
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
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Product List: View Catalog
Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: Acetamidine hydrochloride Request for quotation
CAS: 124-42-5
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: Acetamidine hydrochloride Request for quotation
CAS: 124-42-5
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Acetamidine hydrochloride Request for quotation
CAS: 124-42-5
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Wuhan Xingzhongcheng Chemical limited company
Spot supply
Product Name: Acetamidine hydrochloride Request for quotation
CAS: 124-42-5
Tel: 86+027-83389957
Email: 1024042217@qq.com
Mobile: 86+18627766980
QQ: 1024042217 Click to send a QQ message
Wechat: 18627766980
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: Acetamidine hydrochloride Visit Supplier Webpage Request for quotation
CAS: 124-42-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Shanghai Worldyang Chemical Co.,Ltd.
Product Name: Acetamidine hydrochloride Request for quotation
CAS: 124-42-5
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228 Click to send a QQ message
Wechat: 13651600618
WhatsApp: +8613651600618
Hangzhou Verychem Science And Technology Co.Ltd
Product Name: Acetamidine hydrochloride Request for quotation
CAS: 124-42-5
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302 Click to send a QQ message
Product List: View Catalog
View History
Acetamidine HCl
Raw Materials for Acetamidine HCl
Methyl alcohol
Methyl alcohol
Chlorosulfonic acid
Ammonia
Acetonitrile
Phosphoric acid
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